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Search Results for " complement c5 "

Targets Recommended: Complement System

16

抑制剂 & 化合物

16

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10863	Complement C5-IN-1	Complement System	Immunology/Inflammation
	Complement C5-IN-1 (Compound 7) 是补体成分蛋白5 (C5) 的小分子抑制剂。 Complement C5-IN-1 与 C5 相互作用以防止其被 C5 转化酶切割, 阻断酵母多糖诱导的 50％人全血 MAC 沉积的 IC50 值为 0.77 μM。
T9915	Eculizumab	Complement System	Immunology/Inflammation
	Eculizumab 是针对补体 C5 的长效人源化单克隆抗体。它对 C5 裂解为 C5a 和 C5b 具有抑制作用，并抑制了末端补体系统的部署，其中包括膜攻击复合物的形成。它可用于溶血的研究。
T76867	Ravulizumab ALXN1210	Complement System	Immunology/Inflammation
	Ravulizumab (ALXN1210) 是一种靶向补体因子 5 的人源化单克隆抗体，它以高亲和力特异性结合人补体蛋白 C5，可阻断补体激活。Ravulizumab 可用于预防和治疗阵发性睡眠性血红蛋白尿症、非典型溶血性尿毒症综合征和重症肌无力。
T77022	Gefurulimab
	Gefurulimab(ALXN-1720) 是一种人源的抗补体 C5和白蛋白的双特异性抗体，可结合 C5 并阻止其激活。
T75106	ARC186
	ARC 186 是一种核酸适配体，是高效的补体抑制剂，通过阻断转化酶催化的C5 激活发挥作用。
T74550	Cemdisiran, terminal sugar modification-
	Cemdisiran（终端糖基修饰）是一种靶向C5 mRNA的siRNA，通过N-乙酰半乳糖胺缀合增强RNAi活性，能够抑制肝脏中补体成分C5的生成。
T77121	Pozelimab
	Pozelimab (REGN3918)为一种针对component 5 (C5) 的人源IgG4单克隆抗体。其通过高亲和力结合C5及其变体，有效阻断补体介导的溶血作用，适用于对补体介导疾病进行研究。
T77190	Crovalimab
	Crovalimab (SKY59; RO7112689)是一种人源化抗C5抗体，其通过pH依赖性机制发挥作用，其KD值在pH 7.4时为15.2nM，在pH 5.8时为16.8μM。该化合物还以高亲和力结合于人FcRn(KD: 17μM; pH 6.0)。通过阻断C5转化酶对C5的切割及抑制C5变体(p.Arg885His)的活性，Crovalimab能够显著抑制补体系统中经典途径(CP)、凝集素途径(LP)以及旁路途径(AP)中C5b-9的形成。因此，Crovalimab展现出作为研究阵发性睡眠性血红蛋白尿(PNH)及其他补体介导疾病的潜力。
T74551	Avacincaptad pegol sodium
	Avacincaptad pegol (ARC1905) 是一种靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Avacincaptad pegol 被用于研究与年龄相关的黄斑变性(AMD)。
T74431	Cemdisiran
	Cemdisiran 是一种 GalNAc 偶联的 siRNA 干扰，通过抑制肝脏补体5 (C5)蛋白的产生来研究补体介导的疾病。
T76276	Zilucoplan
	Zilucoplan (RA101495)为含15个氨基酸的大环肽，兼作有效的补体成分5 (C5) 抑制剂，适用于免疫介导的坏死性肌病 (IMNM) 研究。
T80083	Zilucoplan TFA RA101495 TFA	Complement System	Immunology/Inflammation
	Zilucoplan TFA (RA101495)为含15个氨基酸的大环肽，有效抑制补体组分5 (C5)。该化合物适用于免疫介导的坏死性肌病 (IMNM) 研究。
T74552	Non-PEGylated/naked ARC1905
	Non-PEGylated/naked ARC1905 是一种没有偶联PEG 的靶向补体因子5 (C5)的核酸适配体，抑制C5剪切为C5a 和C5b。Non-PEGylated/naked ARC1905 被用于研究与年龄相关的黄斑变性(AMD)。
T74699	Avacincaptad pegol
	Avacincaptad pegol 是核酸适配体，作为 C5 补体抑制剂，用以减轻炎症导致的视网膜色素上皮 (RPE) 损伤。该化合物可用于研究 stargardt 黄斑营养不良 (STGD1) 与地理萎缩 (GA)。
T78191	NH2-C6-ARC186	Complement System	Immunology/Inflammation
	NH2-C6-ARC186是带有NH2-C6接头的ARC186衍生物，可用于与其他肽或分子偶联。它作为一种适体，是一种高效的补体抑制剂，通过抑制转化酶催化的C5活化发挥作用。
T77163	Pexelizumab
	Pexelizumab (h5G1.1-SC)为一种针对C5补体成分的人源化单克隆抗体。该化合物可抑制凋亡(apoptosis)和白细胞浸润，常用于研究脑缺血再灌注损伤和心肌梗死。

化合物

Complement C5-IN-1

Cat.No: T10863

Target: Complement System

Cat.No: T9915

Target: Complement System

Cat.No: T76867

Synonym: ALXN1210

Target: Complement System

Cat.No: T77022

Cat.No: T75106

Cemdisiran, terminal sugar modification-

Cat.No: T74550

Cat.No: T77121

Cat.No: T77190

Avacincaptad pegol sodium

Cat.No: T74551

Cat.No: T74431

Cat.No: T76276

Cat.No: T80083

Synonym: RA101495 TFA

Target: Complement System

Non-PEGylated/naked ARC1905

Cat.No: T74552

Avacincaptad pegol

Cat.No: T74699

Cat.No: T78191

Target: Complement System

Cat.No: T77163

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00653	Complement C5 Protein, Human, Recombinant (Complement C5a) C5D,C5b,CPAMD4,complement compone...	Human	E. coli
	Complement C5 Protein, Human, Recombinant (Complement C5a) is expressed in E. coli expression system. The predicted molecular weight is 8.3 kDa and the accession number is P01031.
TMPY-05057	Complement C5 Protein, Human, Recombinant (His & FLAG) C5b,ECLZB,C5a,CPAMD4,C5D,comp...	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 188.8 kDa and the accession number is P01031.
TMPH-03270	Complement C5 Protein, Rat, Recombinant (His & Myc) Complement C5,C5	Rat	E. coli
	Complement C5 Protein, Rat, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.0 kDa and the accession number is P08650.
TMPY-06814	Complement C5 Protein, Human, Recombinant (Flag) C5a,CPAMD4,ECLZB,C5b,C5D,Comp...	Human	HEK293 Cells
	Complement C5 Protein, Human, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 187.36 kDa and the accession number is NP_001726.2.
TMPH-03107	Complement C5a Protein, Pig, Recombinant (His) Complement C5a anaphylatoxin,C5	Sus scrofa (Pig)	P. pastoris (Yeast)
	Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation....
TMPY-06137	Complement C5 Protein, Cynomolgus, Recombinant (His) complement component 5	Cynomolgus	HEK293 Cells
	Complement C5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 188.1 kDa and the accession number is XP_005580972.1.
TMPY-06538	Complement C5 Protein, Cynomolgus, Recombinant complement component 5	Cynomolgus	HEK293 Cells
	Complement C5 Protein, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 8.41 kDa and the accession number is XP_005580972.1.
TMPK-01268	Complement C2 Protein, Cynomolgus, Recombinant (His) C2,CO2,Complement C2,C3/C5 convertase,ARMD...	Cynomolgus	HEK293 Cells
	Single nucleotide polymorphism (SNP) of complement component 2 (C2) has been found to be significantly associated with hepatocellular carcinoma (HCC). Significantly lower C2 expression was found at HCC compared to healthy controls, and C2 was associated with TNM stages. Higher C2 expression was significantly associated with better prognosis, and multivariate analysis showed that C2 was also an independent factor for the prognosis of HCC.
TMPH-02607	Complement factor B Protein, Mouse, Recombinant (His) C3/C5 convertase,Complement factor B,Cfb,B...	Mouse	E. coli
	Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase.
TMPH-03038	Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO) Cobra venom factor,Complement C3 homolog,CVFk,CVF	Naja kaouthia	E. coli
	Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely re...
TMPH-02845	Properdin Protein, Mouse, Recombinant (His & Myc)	Mouse	HEK293 Cells
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPH-02844	Properdin Protein, Mouse, Recombinant (His)	Mouse	E. coli
	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Inhibits CFI-CFH mediated degradation of Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b).
TMPJ-00149	Complement Factor D/CFD Protein, Mouse, Recombinant (His) C3 convertase activator,28 kDa adipocyte protein,Cfd,Adipsin...	Mouse	HEK293 Cells
	Complement factor D, also known as adipsin, is a member of the chymotrypsin family of serine proteases, which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3, which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the...
TMPH-01134	Complement C8g Protein, Human, Recombinant (His) C8G,Complement component C8 gamma chain	Human	E. coli
	C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. Complement C8g Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is P07360.
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His) C3 and PZP-like alpha-2-macroglobulin domain-containing prot...	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
TMPJ-00585	Complement C8 gamma Protein, Human, Recombinant (His) C8 γ,Complement component C8 gamma chain,C8G,Co...	Human	E. coli
	Complement component C8 is a constituent of the membrane attack complex, C8 alpha, C8 beta and C8G. C8G is a secreted protein and comsists a disulfide-linked C8 alpha-gamma heterodimer and a non-covalently associated C8 beta chain. C8 alpha and C8 beta play an important role in complement-mediated bacterial killing together.C8 is involved in the formation of Membrane Attack Complex on bacterial cell membranes. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a...

重组蛋白

Complement C5 Protein, Human, Recombinant (Complement C5a)

Cat.No: TMPY-00653

Species: Human

Expression System: E. coli

Complement C5 Protein, Human, Recombinant (His & FLAG)

Cat.No: TMPY-05057

Species: Human

Expression System: HEK293 Cells

Complement C5 Protein, Rat, Recombinant (His & Myc)

Cat.No: TMPH-03270

Species: Rat

Expression System: E. coli

Complement C5 Protein, Human, Recombinant (Flag)

Cat.No: TMPY-06814

Species: Human

Expression System: HEK293 Cells

Complement C5a Protein, Pig, Recombinant (His)

Cat.No: TMPH-03107

Species: Sus scrofa (Pig)

Expression System: P. pastoris (Yeast)

Complement C5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-06137

Species: Cynomolgus

Expression System: HEK293 Cells

Complement C5 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-06538

Species: Cynomolgus

Expression System: HEK293 Cells

Complement C2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01268

Species: Cynomolgus

Expression System: HEK293 Cells

Complement factor B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02607

Species: Mouse

Expression System: E. coli

Cobra venom factor Protein, Naja kaouthia, Recombinant (His & SUMO)

Cat.No: TMPH-03038

Species: Naja kaouthia

Expression System: E. coli

Properdin Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02845

Species: Mouse

Expression System: HEK293 Cells

Properdin Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02844

Species: Mouse

Expression System: E. coli

Complement Factor D/CFD Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00149

Species: Mouse

Expression System: HEK293 Cells

Complement C8g Protein, Human, Recombinant (His)

Cat.No: TMPH-01134

Species: Human

Expression System: E. coli

Complement C4-B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02605

Species: Mouse

Expression System: E. coli

Complement C8 gamma Protein, Human, Recombinant (His)

Cat.No: TMPJ-00585

Species: Human

Expression System: E. coli

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